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Deciphering Host-Virus Interactions and Improving Therapy for Chronic Viral Infection

Heory

Chronic viral infections such as HIV and HBV pose a serious threat to human health, leading to significant mortality and new infections each year. Despite progress, our knowledge of virus-host immune interactions, pathogenic mechanisms of inflammation, and disease progression remains incomplete.
This Research Topic examines in detail the complex interactions between chronic viral infections and the host immune system and aims to uncover how inflammation induced by aberrant immune activation or immune exhaustion impairs effective antiviral responses and seeks to elucidate the underlying mechanisms of chronic viral infections by investigating the causal relationships between pathogenesis and disease progression. Specifically, it focuses on elucidating the role of specific immune cells and pathways involved in these processes. Emphasis is placed on understanding the viral infection pathway, metabolic mechanisms of the immune system, pro-inflammatory pathways, cell death processes, and complex T and B cell responses, particularly virus-specific T and B cell responses. Ultimately, this research aims to pioneer innovative therapeutic strategies to effectively treat and potentially cure chronic viral diseases such as AIDS and chronic hepatitis B. Through this exploration, the goal is to advance our understanding of the host immune response to chronic viral infections, particularly AIDS and CHB, paving the way for new interventions that could mitigate the profound global health impact of these infections.

1. Regulatory mechanisms of cellular immune metabolism during viral infection (e.g. HIV, HBV, etc.): how immune cell metabolism is regulated, including processes such as glycolysis and mitochondrial metabolism, and how these mechanisms contribute to the antiviral defense of the immune system. Focuses on understanding the metabolic pathways and signals that influence the functionality of immune cells in combating viral infections.
2. Pathogenic mechanisms of viral inflammation: investigate how viral infections, particularly HIV and HBV, induce tissue inflammation and pathological damage. The goal is to identify the molecular and cellular pathways that trigger the inflammatory response, elucidating their role in tissue damage and disease progression.
3. Innovative therapeutic strategies for AIDS and CHB: novel therapeutic approaches aimed at achieving functional cures for AIDS and chronic hepatitis B (CHB). This includes the exploration of novel treatment modalities such as immunotherapies (e.g. anti-PD-1, anti-PD-L1 therapies), personalized vaccine strategies, gene and cell therapies, and combination therapies.


Keywords:Virus-host immune interaction


Important note: All work within this Research Topic must be within the scope of the section and journal to which it is submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

Chronic viral infections such as HIV and HBV pose a serious threat to human health, leading to significant mortality and new infections each year. Despite progress, our knowledge of virus-host immune interactions, pathogenic mechanisms of inflammation, and disease progression remains incomplete.
This Research Topic examines in detail the complex interactions between chronic viral infections and the host immune system and aims to uncover how inflammation induced by aberrant immune activation or immune exhaustion impairs effective antiviral responses and seeks to elucidate the underlying mechanisms of chronic viral infections by investigating the causal relationships between pathogenesis and disease progression. Specifically, it focuses on elucidating the role of specific immune cells and pathways involved in these processes. Emphasis is placed on understanding the viral infection pathway, metabolic mechanisms of the immune system, pro-inflammatory pathways, cell death processes, and complex T and B cell responses, particularly virus-specific T and B cell responses. Ultimately, this research aims to pioneer innovative therapeutic strategies to effectively treat and potentially cure chronic viral diseases such as AIDS and chronic hepatitis B. Through this exploration, the goal is to advance our understanding of the host immune response to chronic viral infections, particularly AIDS and CHB, paving the way for new interventions that could mitigate the profound global health impact of these infections.

1. Regulatory mechanisms of cellular immune metabolism during viral infection (e.g. HIV, HBV, etc.): how immune cell metabolism is regulated, including processes such as glycolysis and mitochondrial metabolism, and how these mechanisms contribute to the antiviral defense of the immune system. Focuses on understanding the metabolic pathways and signals that influence the functionality of immune cells in combating viral infections.
2. Pathogenic mechanisms of viral inflammation: investigate how viral infections, particularly HIV and HBV, induce tissue inflammation and pathological damage. The goal is to identify the molecular and cellular pathways that trigger the inflammatory response, elucidating their role in tissue damage and disease progression.
3. Innovative therapeutic strategies for AIDS and CHB: novel therapeutic approaches aimed at achieving functional cures for AIDS and chronic hepatitis B (CHB). This includes the exploration of novel treatment modalities such as immunotherapies (e.g. anti-PD-1, anti-PD-L1 therapies), personalized vaccine strategies, gene and cell therapies, and combination therapies.


Keywords:Virus-host immune interaction


Important note: All work within this Research Topic must be within the scope of the section and journal to which it is submitted, as defined in their mission statements. Frontiers reserves the right to refer an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.